Det var fileørst mot slutten av 1800-tallet at en tysk kjemiker fant ut at effekten skyldtes acetylsalisylsyre. Det fikk legemiddelfirmaet Bayer til å utvikle Aspirin, som raskt ble en stor suksess verden in excess of.Biholebetennelse går vanlegvis in excess of utan behandling. Reseptfrie smertestillande som paracetamol eller ibuprofen kan lindr
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